AZD 5597 ( AZD5597;AZD-5597 )

Catalog No. M16626 CAS No. 924641-59-8

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Product Name

AZD 5597
Note

Research use only, not for human use.
Brief Description

A highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM.
Description

A highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM, demonstrates anticancer activity in SW620 tumour xenograft, possesses suitable physiochemical and pharmacokinetic profiles for intravenous (i.v.) dosing.
Synonyms

AZD5597;AZD-5597
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

924641-59-8
Formula Weight

437.51
Molecular Formula

C23H28FN7O
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC=C(NC2=NC=C(F)C(C3=CN=C(C)N3C(C)C)=N2)C=C1)N4C[C@@H](NC)CC4
Chemical Name

(S)-(4-((5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone

1. Jones CD, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73.

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