Cart
sales@molnova.com
AZD 5597
CAS No. 924641-59-8
AZD 5597( AZD5597 | AZD-5597 )
Catalog No. M16626 CAS No. 924641-59-8
A highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 290 | Get Quote |
|
| 10MG | 464 | Get Quote |
|
| 25MG | 754 | Get Quote |
|
| 50MG | 1044 | Get Quote |
|
| 100MG | 1404 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAZD 5597
-
NoteResearch use only, not for human use.
-
Brief DescriptionA highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM.
-
DescriptionA highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM, demonstrates anticancer activity in SW620 tumour xenograft, possesses suitable physiochemical and pharmacokinetic profiles for intravenous (i.v.) dosing.
-
In Vitro——
-
In Vivo——
-
SynonymsAZD5597 | AZD-5597
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number924641-59-8
-
Formula Weight437.513
-
Molecular FormulaC23H28FN7O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (228.57 mM)
-
SMILESO=C(C1=CC=C(NC2=NC=C(F)C(C3=CN=C(C)N3C(C)C)=N2)C=C1)N4C[C@@H](NC)CC4
-
Chemical Name(S)-(4-((5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Jones CD, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73.
molnova catalog
related products
-
THZ-1 hydrochloride
THZ-1 hydrochloride is a potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM; also weakly inhibits CDK12 with IC50 of 250 nM.
-
Aminopurvalanol A
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 nM and 20 nM, respectively.
-
NU-6102
A potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
